Air defenses destroyed 65 of the drones on approach to the capital, Sobyanin said, while the rest were "neutralized by air defense forces at long range." No casualties were reported.
TASS called it one of the largest attempted attacks on Moscow since the start of the year.
Three Moscow airports — Domodedovo, Vnukovo and Zhukovsky — imposed temporary flight restrictions overnight.
In the Kaluga region, air defenses destroyed 73 drones, regional head Vladislav Shapsha said. In Mosalsky district, the attack damaged a school building, two private houses and a car. No one was hurt.
Stavropol Krai Governor Vladimir Vladimirov said air defenses repelled a "massive air attack" on the region overnight. According to him, "damage from fallen UAV debris was recorded" in the industrial zone of Nevinnomyssk. Inspections of the crash sites and assessments of the consequences are ongoing, and work to repair the damage has begun. He gave no other details.